Day 1: November 6
Time Duration Session Description
8:30 – 9:0030 minRegistration, Tea/Coffee (Continues through lunch)
9:00 – 9:1515 minWelcome & Introduction
9:15 – 10:0045 minInaugural Address / Keynote
10:00 – 11:15 75 min AI-Enabling Mission to Mars — Part I
This session brings NASA, Industry, and University experts together to address the use of AI for autonomous robotic operations, repair, maintenance, logistics of systems during long periods of time without crew presence. These activities will include preparation of systems for crew arrival and reconfiguration of systems after crew departure. One major question to be addressed is how to bring existing/new terrestrial space-related expertise to Mars? This includes how to provide terrestrial value in advance of a mission and how to provide it in near-real-time. And how do we enable AI tools to develop expertise independently during the mission?
11:15 – 11:4530 minShort Pitches & Poster Highlights: Startups / Commercial Vendors
11:45 – 12:4560 minLunch + Poster Session / Demos
12:45 – 14:00 75 min AI-Magnified Strategic Economic Presence in Cis-Lunar Space — Part I
This session brings together NASA, industry leaders, and university researchers to examine the pivotal role of artificial intelligence in advancing computing and data infrastructure for space. Discussions will focus on how AI can enable resilient, autonomous, and energy-efficient data centers in low Earth orbit (LEO) and cis-lunar space, addressing challenges such as limited power, harsh environments, and communication delays. Panelists will highlight applications from real-time data processing for satellite constellations and space habitats to AI-driven optimization of cloud services linking Earth and space. By convening thought leaders across government, academia, and industry, this session will show how AI-enabled computing underpins a sustainable economic presence in space, supporting long-duration exploration, commercial activity, and scientific discovery.
14:00 – 15:15 75 min Defending the Homeland — Part I
This session brings industry, defense agencies, and academia experts together to identify critical In-Space Physical AI capabilities and needs for the nation’s Golden Dome initiative. We will focus on immediate needs to securely integrate existing systems as well as the longer-term development of AI-enabled systems for threat detection, decision making, operations, and vehicle design. The goal for this session is to guide federal and private industry priorities and forge strategic industry-defense-academia partnerships to create mission-ready space-based defense solutions.
15:15 – 15:4530 minTea/Coffee Break
15:45 – 17:30105 minInternational Collaboration
18:00 – 20:00120 minWelcome Reception & Networking
Day 2: November 7
Time Duration Session Description
8:30 – 9:0030 minTea/Coffee (Continues through lunch)
9:00 – 9:1515 minWelcome
9:15 – 10:00 45 min Keynote / Fireside Chat
Featuring keynote speaker Steve Smith, Director, Flight Systems at Blue Origin.
10:00 – 11:15 75 min AI-Enabling Mission to Mars — Part II
This session will bring together Subject Matter Experts to address the use of AI to aid Astronauts in complex tasks during which they would historically have had MCC-based advice/assistance. (e.g., Medical activities, Flight Operations, Flight systems troubleshooting and repair, Science Operations). One consideration will be the use of AI to deal with light-time communication delays faced during a Mars Mission, which will result in limited and potentially confusing communications between terrestrial support capabilities and vehicle crew and systems. Another major topic will be the use of AI to deal with shifts between robotic, crew-tended, and hybrid crew & robotic teaming for operations of complex systems (e.g., an ISRU plant).
11:15 – 11:4530 minFeatured Speaker: Government / Industry / Academia
11:45 – 12:4560 minLunch + Poster Session / Demos
12:45 – 14:00 75 min AI-Magnified Strategic Economic Presence in Cis-Lunar Space — Part II
This session brings together experts from NASA, industry, and academia to explore the expanding role of artificial intelligence in healthcare for low Earth orbit (LEO) and cis-lunar space. Discussions will highlight advances in AI-enabled sensing for continuous health monitoring, intelligent rehabilitation technologies for performance optimization, and predictive analytics for early intervention. Special attention will focus on astronaut health in extreme environments, including vital sign monitoring, musculoskeletal support, and psychological well-being. Panelists will also discuss how these space-driven innovations translate to Earth, enabling smarter wearables, personalized rehabilitation, and improved care delivery in resource-limited settings. Together, these perspectives will outline how AI can transform healthcare monitoring, rehabilitation, and long-term health management.
14:00 – 15:15 75 min Defending the Homeland — Part II
The Physical AI (PAI) augmented operations session focuses on integrating robust, verified PAI systems to advance autonomous operations in space defense. We will highlight emerging methodologies and technology for enabling intelligent, secure, adaptive, autonomous, and scalable capabilities for national security. The discussion will center on translating research into deployable systems, aligning with mission-driven funding, and forming strategic partnerships with industry, defense agencies, and academia. The goal for this session is to define a roadmap and partnerships for operationalizing assured Physical AI in space operations.
15:15 – 15:3015 minClosing & Wrap-Up
15:30 – End~30+ minWriting Session:
– Create/Review AI Summary of Meeting
– Summary of Insights and Next Steps